Cyclopen

 
     
 

DESCRIPTION

Ophthalmic solution Cyclopen‚ in the 10 mL dispenser bottle is a topical solution containing Cyclopentolate Hydrochloride 10 mg (1%) in each milliliter of buffered solution. Benzalkonium Chloride 0.01% added as preservative.
Cyclopentolate Hydrochloride is 2-Dimethylaminoethyl-2-(1-Hydroxycyclopentyl)-2-Phenylacetate Hydrochloride. Its empirical formula is C17H25NO3◊HCl. Cyclopentolate Hydrochloride is freely soluble in water. Its molecular weight is 327.9.
 

ACTIONS/CLINICAL PHARMACOLOGY

* Cyclopentolate Hydrochloride is an antimuscarinic agent with actions similar to those of atropine. It is used as eye drops to produce cycloplegia and mydriasis. It acts more quickly than atropine and has a shorter duration of action; the maximum effect is produced 30 to 60 minutes after instillation; accommodation recovers within 24 hours but may be hastened if 1 or 2 drops of a 2% solution of Pilocarpine are instilled.
* Cyclopentolate Hydrochloride eye drops can be used in association with carticosteroid eye drops to treat chronic uveitis.
 

INDICATIONS AND USAGE

Cycloplegia for refractometry in latent and facultative hyperopia; mydriasis for funduscopy
 

CONTRAINDICATIONS

Glaucoma; prostatic enlargement
 

WARNINGS

Cyclopen‚ should not be given to patients with closed-angle glaucoma or to patients with a narrow angle between the iris and the cornea. Due to the risk of provoking hyperpyrexia it should not be given to patients, especially children, when the ambient temperature is high. It should also be used cautiously in patients with fever.
 

PRECAUTIONS

Cyclopen‚ should be used with caution in children and in geriatric patients, who may be more susceptible to its adverse effects. It is contraindicated in patients with prostatic enlargement. It should be cautiously given to patients with diarrhoea. It should be used with extreme caution in myasthenia gravis. Cyclopen‚ should be used with caution in conditions characterized by tachycardia.
 

ADVERSE REACTIONS

Dryness of the mouth with difficulty in swallowing and talking; thirst; dilation of pupils with loss of accommodation; photophobia; flushing and dryness of the skin; transient bradycardia followed by tachycardia; may cause temporary irritation.
 

DOSAGE AND ADMINISTRATION

For refraction, 1 drop of Cyclopen‚ repeated after about 5 to 15 min is usually sufficient, but more deeply pigmented eyes may require higher doses.
 

HOW SUPPLIED

10 mL in plastic dropper bottle (Sterile).
REFRIGERATE UNTIL DISPENSED.