DESCRIPTION
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Homatropine is a sterile solution containing homatropine hydrobromide (2%) and benzalkonium chloride as preservative. It is moderately long-acting mydriatic and cycloplegic used for refraction and in the treatment of inflammatory conditions of the uveal tract.
Homatropine hydrobromide is (1R, 3r, 5S)-3-([RS]-2-hydroxy-2-phenylacetoxy)-8-methyl-8-azabicyclo[3.2.1]octane hydrobromide. It is a white crystalline powder with a molecular weight of 356.3. It is freely soluble in water, sparingly soluble in alcohol very slightly soluble n ether. Its empirical formula is C16H21NO3·HBr. |
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ACTIONS/CLINICAL PHARMACOLOGY |
Homatropine is an antimuscarinic agent with effects similar to, but
weaker than, those of atropine; when applied to eyes its cycloplegic and
mydriatic actions are more rapid and of shorter duration.
For this reason it may be preferred to atropine for these purposes. However,
it is not a reliable cycloplegic in very young people because of their
strong accommodative reserve. |
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INDICATIONS AND USAGE |
| Homatropin 2% is used for the determination of refraction and in the treatment
of uveitis. |
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CONTRAINDICATIONS |
| Homatropin is contraindicated in persons with primary glaucoma or
a tendency towards glaucoma and in persons showing hypersensitivity to
homatropine. |
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WARNINGS |
| As for Ethiatropin |
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ADVERSE REACTIONS |
| As for Ethiatropin |
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DOSAGE AND ADMINISTRATION |
Refraction
Instill one or two drops, repeat if necessary 5 or 10 min later.
Uveitis
One or two drops usually 2 or 3 times daily. |
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HOW SUPPLIED |
| In 15mL and plastic dropper bottles. |
